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Non-small cell lung cancer insulin-like growth factor Ⅰ receptor expression and clinical significance

C and normal lung tissue were analyzed,[link widoczny dla zalogowanych], the results found that IGF-IR in NSCLC tissue and adjacent normal tissue have different levels of expression. Positive parts of brownish yellow, located in the cell membrane, cytoplasm is also a small amount of coloring, which may be due to IGF-IR and ligand binding to the cells resulting from the movement. These results suggest that, NSCLC tissue expression of IGF-IR levels and normal lung tissue was significantly different. Positive rate of NSCLC, accounting for 82.54%, which accounted for strong expression of 36.5I% (23/63),[link widoczny dla zalogowanych], adjacent normal lung tissue did not express or weakly positive for expression-based. Comparative Analysis of the results of this study suggest: IGF-IR may be involved in the NSC [C occurrence or development process, and in maintaining the malignant phenotype plays an important role. Thus, to further explore NSCLCIGF-IR expression in clinical and pathological features are very necessary. We collected the clinical data of 63 patients with NSCLC, of different degrees of IGF-IR expression and gender, age, smoking, histological type, differentiation, tumor size and lymph node metastasis between the clinical characteristics, can be seen from Table 2 : poorly differentiated NSCLC in 30 patients, 27 cases of positive expression of IGF-IR, of which 50% (15/30) were strongly positive. Scores of the 15 cases of NSCLC, only 1 was strongly positive cases, accounting for 6.67% (1 / 15); 7 cases of negative expression, accounting for 46.67% (7 / 15). The results also show that: IGF-IR expression or not,[link widoczny dla zalogowanych], the expression is closely related to the degree of differentiation, suggesting that IGF-IR may be by influencing cell differentiation in NSCLC, their development and maintenance of the malignant phenotype has played an important role. However, due to fewer cases of the experimental samples, the possibility for the IGF-IR as a diagnostic and prognostic indicators of NSCLC remains to be confirmed by further studies. If further studies confirm the conclusions of this study, IGF-IR that may be of clinical diagnosis and prognosis of NSCLC a new target. Combined with our previous research,[link widoczny dla zalogowanych], the use of IGF-IR antibody or IGF-IR by antisense IGF-IR blocking technologies such as the signal transduction pathway, can inhibit the growth of NSCLC cells and promote apoptosis in NSCLC cells. This treatment and prevention of NSCLC provides new methods and ideas. [
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