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The investigators hypothesized that the principle effects of acupuncture are due to the stimulation of endogenous opioid peptides and the related immune system benefits. These effects are similar to those attributed to low-dose naltrexone, an oral medicine that also raises endogenous opioid peptide levels. Several studies have previously demonstrated that acupuncture induces production of endogenous opioid peptides, particularly beta-endorphin.
Effects of Acupuncture
In one recent study, physicians studied the physiological changes such as cytokine levels related to acupuncture treatments administered to hospital employees, both males and females between the ages of 24 and 50 years. Each of the study participants had an L1 4 acupuncture treatment and two weeks later had a sham treatment (similar session but with needles administered to non-acupuncture points). Before and after both sessions, subjects were tested for vital signs and for levels of interferon-gamma (IFN-γ) and interleukin-2 (IL-2).
The investigators also noted the impo
During acupuncture [link widoczny dla zalogowanych], 50 mm blunt-tipped stainless steel needles were applied to the L1 4 acupuncture points bilaterally. This point corresponds to the large intestine principal meridian, which is located on the hand in the center dorsal interosseous muscle between the 1st and 2nd metacarpal bones. The needles were kept in this position for 20 minutes with alternating continual counterclockwise rotation for 10 seconds every 5 minutes.
Study Design
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Benefits of Low Dose Naltrexone
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Study Results
According to current theories of modern anatomy and physiology [link widoczny dla zalogowanych], acupuncture points are related to areas on the skin surface with lower electrical conduction compared to that of their immediate environment. These acupuncture points appear to correspond to cranial and peripheral nerve endings.
The analgesic effects of acupuncture have been extensively documented and have been shown to be mediated partially by the stimulation of endogenous (the body’s own natural) opioid peptide compounds. However, besides these endorphins, other natural non-endorphin peptides may be produced. In addition, acupuncture has been shown to modulate immunoglobulins (proteins from which antibodies are made) and enhance the activity of the white blood cells known as natural killer (NK) cells and the phagocytes. Acupuncture has also been reported to stimulate production of the cytokines interferon-gamma (IFN-γ) and interleukin-2 (IL-2) [link widoczny dla zalogowanych], and suppress the pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-10 (IL-10).
Among Eastern medical practitioners, acupuncture is considered standard therapy. Among Western practitioners, acupuncture is considered an effective holistic therapy for reasons that remain unclear. Because acupuncture has been proven highly effective in patients with autoimmune disorders and various cancers, researchers have suspected immune system involvement.
Sham treatments were performed exactly as the LI 4 treatments, except that the needles were applied at non-acupuncture points approximately 1 inch from the LI 4 site bilaterally. It is thought that application of needles to non-acupuncture sites does not elicit the Qi stimulation induced at acupuncture points.
The measurement of Qi was conducted by assessing the responses of subjects to the acupuncture stimulation. All subjects receiving acupuncture reported increased Qi. Blood pressure and heart rate were not affected by acupuncture. Two subjects showed a slight increase in cytokine levels following acupuncture, but no significant sustained increases in cytokine levels were seen.