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Nm23-H1 protein expression in breast cancer research

Potential. Has been found in the human genome there are two nm23 genes,[link widoczny dla zalogowanych], respectively nm23 H1 and nm23 an H2 one that l_3 】 . nm23 H a H and a coding for nm23 nucleoside phosphorylase kinase (NDPK) A, B, two subunits , the molecular weight are 17kd, nm23 an H: protein expression and cancer metastasis, and nm23 H is a degree of tumor differentiation Relevant] . Foreign literature ,[link widoczny dla zalogowanych], nm23 expression and lymph node metastasis and prognosis , with low expression rate of lymph node metastasis , poor prognosis population ]. However, other reports found no Hahnel Hm23 gene in breast cancer metastasis has occurred showed decreased expression of regularity , but also found nm23 gene and metastasis of breast cancer J]. The paradox of the findings is currently no satisfactory explanation of this group of patients showed a H nm23 protein expression and tumor metastasis was a negative correlation ,[link widoczny dla zalogowanych], low-risk metastasis nm23 protein expression in H than a high-risk group , but not with tumor Independent of body size , consistent with the foreign literature nm23 _5_ one of the group H. Protein expression with histological grade PCNA index was no significant correlation , suggesting that nm23 gene can suppress tumor metastasis , but not inhibition of tumor growth. The H protein and nm23 an MDR. PgP no significant correlation between expression and Pgp and the MDR of a tumor -related drug resistance to chemotherapy . Show that the drug does not affect the tumor or without tumor / im23 an H protein. The group / im23 an H protein expression and ER, PR expression in breast cancer prognosis is relatively good , it prompted rim23 a strong expression of H protein in breast cancer with good prognosis of this group of patients through the study of a H protein that nm23 Reduce the level of expression of lymphatic metastasis in breast cancer risk factors . Therefore ,[link widoczny dla zalogowanych], nm23 a H. Protein can be used as clinical breast cancer metastasis, recurrence and prognosis of a reliable monitoring indicators. I believe that with the molecular pathology of tumor metastasis continuous access , there is hope to clarify rim23 gene and multiple genes and breast cancer metastasis , and to find effective new ways to stop cancer metastasis and metastasis notice of the effective markers of risk

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